Generic Tobramycin Elutes From Bone Cement Faster Than Proprietary Tobramycin
نویسندگان
چکیده
منابع مشابه
The pharmacokinetics of Simplex-tobramycin bone cement.
We prospectively investigated a consecutive series of ten patients undergoing a cemented primary total hip replacement (THR) for osteoarthritis in order to establish the elution characteristics of Simplex-tobramycin bone cement (Howmedica, Limerick, Ireland). Specimens of blood, urine and drainage fluid were collected for 72 hours postoperatively. Very high concentrations of tobramycin were fou...
متن کاملAddition of hand-blended generic tobramycin in bone cement: effect on mechanical strength.
This study compared the mechanical strength of commercially prepared antibiotic bone cement (Simplex With Tobramycin; Stryker, Mahwah, NJ), cement with generic tobramycin (Pharma-Tek, Huntington, NY) blended in by the orthopedic nursing staff, and standard nonantibiotic bone cement. The results showed an approximate 36% decrease in the strength of the cement with hand-mixed generic tobramycin, ...
متن کاملFixed exanthema from systemic tobramycin.
Eye drops contain several ophthalmic medications which can produce allergic reactions. We report the case of a patient with contact dermatitis from neomycin and a probable fixed exanthema after parenteral administration of tobramycin who tolerated topical tobramycin and other aminoglycosides.
متن کاملAcute Kidney Injury With Tobramycin-Impregnated Bone Cement Spacers in Prosthetic Joint Infections.
BACKGROUND Antibiotic-impregnated bone cement spacer (ACS) with tobramycin ± vancomycin is commonly used in a 2-stage replacement of infected prosthetic joints. This procedure has been associated with development of acute kidney injury (AKI). OBJECTIVE To determine the incidence and risk factors for AKI after implantation of tobramycin-impregnated ACS. METHODS This prospective, observationa...
متن کاملSafeness of Simplex-tobramycin bone cement in patients with renal dysfunction undergoing total hip replacement.
PURPOSE To compare the pharmacokinetic profile of tobramycin in blood, urine, and at the operative site following the use of Simplex-tobramycin bone cement in primary total hip replacement between patients with and without renal dysfunction. METHODS Six patients with renal dysfunction underwent cemented primary total hip replacement for osteoarthritis. The elution characteristics of Simplex-t...
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ژورنال
عنوان ژورنال: Clinical Orthopaedics & Related Research
سال: 2008
ISSN: 0009-921X
DOI: 10.1007/s11999-008-0199-2